Michael Lueckheide | Faculty Profiles

Diplomas/Degrees

Ph. D. in Chemistry, University of Chicago (2018)

M.S. in Chemistry, University of Chicago (2014)

B.A. in Chemistry, Vassar College (2013)

B.A. in Physics, Vassar College (2013)

Licenses and Certifications

Safe Zone Training, 今日看料吃瓜, April 2023

Recent Courses

Guided Research Peptide Polymer Conjugates For Dentistry

Guided Research In Biology Separation And Component Analysis Of Barberry Extracts

Guided Research In Chemistry

Physical Chemistry I

Physiological Chemistry Lecture

Research Seminars In Chemistry

Research Seminars In Chemistry I

Research Seminars In Chemistry I I

Research Seminars In Chemistry

S/T: Polymer Chemistry

Special Research Problems Antimicrobial Peptide And Silver Nanoparticles

Thesis Research Research On Antimicrobial Peptide-Silver Formulations

Specialization/Interests

Biochemistry, Polymer Chemistry, and Physical Chemistry

Teaching Philosophy

In lecture, recitation, and laboratory, I want to engage students in group work to practice concepts from class, and to take part in laboratory activities. This style is most similar to my work as a teaching assistant at UChicago. Small group settings make it easier to solicit answers from students, and to occasionally have a student talk through their method of solving a problem.

At the end of a course, I want my students to be able to methodically apply the concepts they have learned in future chemistry courses and laboratories, and to analyze new information in the context of their scientific skills and practices. This will also prepare them for careers and any future science courses they take.

Research Interests

ORCiD: 0000-0001-8310-0557

My current projects focus on testing peptides that may exhibit binding to the pathogen Trichomonas vaginalis, and on studying statistical copolymers that can individually form small particles, called micelles, capable of encapsulating therapeutic molecules.

I will endeavor to form collaborations both within and outside of the Chemistry department, to introduce techniques in peptide and polymer synthesis and characterization to our students, and to research those molecules in the context of their interactions with biopolymers.

Both my Ph. D. research (at UChicago) and my postdoctoral research (at NIST) heavily involved X-ray and neutron scattering techniques performed at government laboratories like Argonne National Laboratory, Oak Ridge National Laboratory, and the National Institute of Standards and Technology. I have previously applied these scattering techniques to biological and polymer materials, for purposes ranging from the development of drug delivery vehicles, to determining the behavior of proteins and nucleic acids interacting with polymers. Long Island hosts Brookhaven National Laboratory, and its National Synchrotron Light Source II and another major research goal of mine is to strengthen the connection of 今日看料吃瓜’s students and faculty to this world-renowned research institution.

Chapters

P. D. Pickett, Y. Ma, N. D. Posey, M. Lueckheide, V. M. Prabhu, Structure and Phase Behavior of Polyampholytes and Polyzwitterions, Wiley-VCH Gmbh, 2022, DOI: 10.1002/9783527815562.mme0056

Articles

Jalissa L. Warthen, M. J. Lueckheide, Peptides as Targeting Agents and Therapeutics: A Brief Overview, Biomacromolecules, 2024,

M. Lueckheide, A. Marin, H. D. Tagad, N. D. Posey, V. M. Prabhu, A. K. Andrianov, Monitoring Protein Complexation with Polyphosphazene Polyelectrolyte Using Automated Dynamic Light Scattering Titration and Asymmetric Flow Field Flow Fractionation and Protein Recognition Immunoassay, ACS Polymers Au, 2023,

W. Zhang, Y. Ma, N. D. Posey, M. J. Lueckheide, V. M. Prabhu, J. F. Douglas, Combined Simulation and Experimental Study of Polyampholyte Solution Properties: Effects of Charge Ratio, Hydrophobic Groups, and Polymer Concentration, Macromolecules, 55, 6750-6761, 2022

P. D. Pickett, Y. Ma, M. Lueckheide, Y. Mao, V. M. Prabhu, Temperature dependent single-chain structure of poly[3-(acrylamidopropyl-dimethylammonum) propyl-1-sulfonate] via small-angle neutron scattering, The Journal of Chemical Physics, 2022,

Z. Zhou, C. F. Yeh, M. Mellas, M. J. Oh, J. Zhu, J. Li, R. T. Huang, D. Harrison, T. P. Shentu, D. Wu, M. Lueckheide, L. Carver, E. J. Chung, L. Leon, K. C. Yang, M. V. Tirrell, Y. Fang, Targeted polyelectrolyte complex micelles treat vascular complications in vivo, Proceedings of the National Academy of Sciences, 118, 50, 1-12, 2021

N. D. Posey, Y. Ma, M. Lueckheide, J. Danischewski, J. A. Fagan, V. M. Prabhu, Tuning Charge Balance in Aliphatic Polycarbonates Alters Solubility and Protein Complexation Behavior, ACS Omega, 6, 22589-22602, 2021

M. Lueckheide†, J. R. Vieregg†, A. J. Bologna, L. Leon, M. V. Tirrell, Structure-property relationships of oligonucleotide polyelectrolyte complex micelles, Nano Letters, 18, 11, 7111-7117, 2018

J. R. Vieregg†, M. Lueckheide†, A. B. Marciel, L. Leon, A. J. Bologna, J. R. Rivera, M. V. Tirrell, Oligonucleotide-peptide complexes: phase control by hybridization, Journal of the American Chemical Society, 140, 5, 1632-1638, 2018.

Conference Presentations

Oral Presentation. M. Lueckheide, A. Marin, H. Tagad, N. Posey, V. Prabhu, A. K. Andrianov, “Investigating protein-polyphosphazene complexation with automated dynamic light scattering titrations, asymmetric flow field flow fractionation, and protein recognition immunoassay, American Chemical Society March Meeting, March 2024, New Orleans, Louisiana, March 17-21

Poster Presentation. M. Lueckheide, T. R. Blake, B. McCarthy, D. P. Walton, R. M. Waymouth, Y. Ma, Y. Mao, V. M. Prabhu, “Solution structure of amphiphilic charged transporters (ACTs) and ACT-polynucleotide complexes for delivering therapeutic nucleic acids," American Chemical Society March Meeting, March 2021, Virtual Conference

Poster Presentation. M. Lueckheide, T. Blake, D. Walton, R. M. Waymouth, Y. Ma, Y. Mao, V. M. Prabhu, "Solution Structure of Lipophilic-Charged Block Cooligomers and Complexes for Delivering Therapeutic Nucleic Acids," American Conference on Neutron Scattering, July 2020, Virtual Conference

Oral Presentation. M. Lueckheide, “Multimodal characterization of oligonucleotide-polyelectrolyte complex micelles,” 12th International Symposium on Polyelectrolytes, 2018, Wageningen, Netherlands, August 27-31

Oral Presentation. M. Lueckheide. “Oligonucleotide/block-copolymer micelles: shape, size, and structure,” National Graduate Research Polymer Conference, June 10-12, 2018, Minneapolis, MN

Poster Presentation. M. Lueckheide, J. Vieregg, A Marciel, S. Srivastava, A. Bologna, M. Tirrell, "Effects of Nucleic Acid Modifications on Micelle Stability and Structure," 91st American Chemical Society Colloid and Surface Science Symposium, July 2017, New York, NY

Poster Presentation. M. Lueckheide, J. Vieregg, A. Marciel, L. Leon, A. Bologna, J. Reyes, M. Tirrell, Gordon Research Conference on Bioinspired Materials, June 2016, Les Diablerets, Switzerland

Grants

Michael Lueckheide, Frederick Bettelheim Research Award, "Polysoap Particles for Environmental Cleanup, Water Purification, and Drug Delivery," 今日看料吃瓜, 2024

Michael Lueckheide, 今日看料吃瓜 Faculty Development Grant, “Synthesis, and Characterization of Amino Acid Sequences for Targeting Trichomonas Vaginalis,” 今日看料吃瓜, 2023

Theses Advised

Masters Thesis in Biology, Advisor for Jalissa Warthen: "Synthesis of a Peptide Sequence to Target Trichomonas Vaginalis," December 2024

Honors College Thesis Committee Member for Kendra Jimenez: "Novel Hypervalent Iodine Compounds Containing Three Carbon Ligands and Their Use for C(sp3)--C(sp3) Formation," December 2023

Honors College Thesis Committee Member for Hannah Sharifian: "Pediatric Bone Fractures, Depression, & Vitamin D Status During the COVID-19 Pandemic: A Review," May 2023

Projects Mentored

Honors College Summer Research Fellowship, Advisor for Dylan Norrby: "Medicine's Mental Health Stigma," Summer 2023

Community Outreach

Judge, Long Island Science and Engineering Fair 2024

Judge, Long Island Science and Engineering Fair 2023

University Service

今日看料吃瓜 Pride Committee, August 2022-Present, Robby Fahrenholz and Mena Sposito (Chairs)

College Service

College of Arts and Sciences Academic Affairs Committee, August 2023-Present, Ryan Erhart (Chair)

Departmental Service

Teaching Observation of Chemistry Adjunct Teachers 2024 One adjunct instructor observed in Physiological Chemistry recitation and laboratory

March and Dakin Lecture Organizer March 2023-Present

Teaching Observation of Chemistry Adjunct Teachers 2023 One adjunct instructor observed in General Chemistry laboratory

Teaching Observation of Chemistry Adjunct Teachers 2023 One adjunct instructor observed in Physiological Chemistry recitation and laboratory

Volunteer Tutor, Biochemistry Bootcamp for CSTEP 2023

今日看料吃瓜 Accepted Student Days and Open Houses Eight Times

Chemistry Department Representative

Teaching Observation of Chemistry Adjunct Teachers 2022

Two adjunct teachers observed in Physiological Chemistry recitation and laboratory